Coventry won 4-1 at Blackburn in the FA Cup third round on Saturday, while Birmingham lost 2-1 at Huddersfield and Bolton also crashed out.Michael Mifsud scored twice as Championship club Coventry booked their place in the fourth round with a memorable victory over Mark Hughes' Rovers at Ewood Park.
The Sky Blues, who dumped Manchester United out of the Carling Cup earlier this season with a 2-0 win at Old Trafford, were again in imperious form against Premier League opposition and never looked in danger of losing the lead given to them through Mifsud's crisp volley after 34 minutes.
They doubled their advantage after 64 minutes when Zurab Khizanishvili was adjudged to have fouled Leon Best in the penalty area and defender Elliott Ward coolly stepped up to fire past Brad Friedel.
Dele Adebola added a third from 18 yards before David Bentley scored a consolation five minutes from time for Mark Hughes' beleaguered side.
Mifsud added a fourth in the dying stages as Iain Dowie's side celebrated a memorable day.
Chris Brandon scored nine minutes from time to secure another cup shock as League One Huddersfield beat Premier League Birmingham.
Luke Beckett handed the Terriers a dream start as he poked home from close range after just four minutes at the Galpharm Stadium but Garry O'Connor levelled for Blues 15 minutes later.
Huddersfield never looked out of place against their more illustrious opponents and Brandon slotted home from close range late on to book their place in the next round.
Bolton left out a string of first-team players, including Chelsea target Nicolas Anelka, and were made to pay as David Carney's solitary strike put Sheffield United through 1-0 at the Reebok Stadium.
And in another surprise result, Paul Scharner's first-half header, Paul McShane's own goal and a neat strike from David Cotterill helped Wigan cruise past Sunderland 3-0 at the Stadium of Light.
Elsewhere, Chelsea were made to work hard for their 1-0 victory over neighbours QPR at Stamford Bridge.
They scored the only goal of the game after 39 minutes in fortuitous circumstances as Claudio Pizarro's shot cannoned off the post before rebounding into the net off the back of Rangers goalkeeper Lee Camp.
Dave Nugent's third goal for Portsmouth secured a 1-0 win at Ipswich, who had Liam Trotter dismissed in the first half.
David Wheater's second-half goal ensured there was no upset at Ashton Gate as Middlesbrough came from behind to see off Bristol City 2-1.
Liam Fontaine had given the hosts the lead inside 20 minutes but Stewart Downing restored parity before Wheater's timely intervention.
Manchester City and West Ham will meet again after a dour 0-0 draw at Upton Park.
Stephen Hunt matched Dimitar Berbatov's brace as Reading secured a 2-2 draw away to Tottenham, who had Tom Huddlestone dismissed for violent conduct.
League Two Peterborough caused an upset against Championship strugglers Colchester as they stormed to a 3-1 win at Layer Road.
Veteran Teddy Sheringham cancelled out Aaron McLean's opener but Darren Ferguson's side stormed back through George Boyd and Charlie Lee.
Gary Doherty cancelled out Andy Bishop's goal as Championship strugglers Norwich salvaged a replay against League Two Bury following a 1-1 draw at Carrow Road.
Blue Square South side Havant and Waterlooville secured a replay against League One leaders Swansea after a memorable 1-1 draw at the Liberty Stadium.
Andy Robinson had looked to have booked the hosts' place in the fourth round before Rocky Baptiste scored with just three minutes remaining to send the visiting support into raptures.
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