Arsenal duo Theo Walcott and Abou Diaby are out of Sunday's trip to Wigan.
Walcott picked up a thigh injury in a behind-closed-doors game against Colorado Rapids on Thursday while Diaby damaged his thigh during the 2-0 Champions League win over AC Milan in the San Siro on Wednesday night.
Robin van Persie played an hour of the game against Colorado but Gunners boss Arsene Wenger is still unsure if he will feature at the JJB Stadium.
Defenders Kolo Toure and Alex Song are set to miss out again.
Wenger told Arsenal TV Online: "From Tuesday night we lost Abou Diaby. He has got a problem on his other calf.
"(On Thursday) we also lost Theo Walcott. He played against Colorado Rapids and he got a little thigh problem.
"Robin played an hour and he looks OK. But it looks early for him, he finished the game very tired today so I will have to analyse that.
"We have a little chance to get Kolo back in the squad and a little, little chance to get Song back.
"As for Tomas Rosicky, it is difficult to say. We hope he'll be back in 10 or 12 days."
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