Kayode Odejayi scored a sensational second-half winner as Barnsley sent FA Cup holders Chelsea crashing out after a thrilling quarter-final tie at Oakwell.
The big Tykes striker climbed above the Barclays Premier League giants' defence to head home Martin Devaney's superb cross in the 65th minute to send most of a sell-out crowd into raptures.
Simon Davey's giant-killers pulled off one of the upsets of the season to dump Liverpool out of the competition in the previous round at Anfield and staggered the football world with another stunning win.
Earlier Portsmouth sent 10-man Manchester United packing by winning a compelling clash 1-0 at Old Trafford, ending their Treble hopes in the process.
The hosts dominated large periods of the match but could not find a way past David James and a defensive backline who were inspired throughout.
And with just 12 minutes left on the clock, Portsmouth broke up the other end and were awarded a penalty when Milan Baros was brought to ground by Tomasz Kuszczak, who was shown a straight red card.
Up stepped Sulley Muntari to hammer home the spot kick past Rio Ferdinand, who donned the gloves for the remainder of the match.
And despite a nervous last few minutes, Harry Redknapp's side held on for a famous triumph.
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