Sir Alex Ferguson admitted it was "disappointing" Manchester United's latest trip to Rome had been scarred by violence once again.
After the appalling scenes at the Stadio Olimpico in April when Italian police baton charged United supporters, at least there was no trouble inside the stadium during the 1-1 Champions League draw with AS Roma.
However, five fans were stabbed outside the ground and needed hospital treatment, further proof the Italian game remains bedevilled by the scourge of hooliganism.
"This is something we hoped would not happen," said Ferguson.
"We wanted a nice quiet night and to be able to go home with no incident. It is disappointing that has not happened.
"Obviously, we are not sure of the details but we hope the supporters concerned will be okay."
Seven Manchester United supporters were taken to hospital after violence flared before the Champions' League clash.
British Embassy officials in Rome said five fans received stab wounds while two others, including a 16-year-old boy, needed treatment for being drunk.
None of the stab victims are understood to have serious injuries following the clash between the rival fans outside the Stadio Olympico. Most are expected to be released by the end of the night, said an embassy spokeswoman.
Earlier the Foreign Office said two British nationals were arrested but embassy staff said they could not confirm if anyone had been detained.
Italian media have reported that six British nationals were arrested by police.
The embassy spokeswoman said: "Seven Manchester United supporters were taken to hospital after fighting broke out on the Pont Duca d'Aosta bridge which fans cross over the river to get to the stadium.
"Five are receiving treatment for stab wounds while two others, one who was a 16-year-old boy, were understood to be drunk.
"Their injuries are not thought to be serious and most of them will be discharged in the next couple of hours. One person may be kept in overnight for observation.
"The situation in the stadium is now fine and everything is running smoothly."
She added she could not confirm if any Britons had been arrested.
The embassy had warned travelling fans beforehand not to use the Pont Duca d'Aosta bridge because it was habitually used by Roma's notorious Ultras - a following of hardcore fans.
Scenes of violence and disorder marred the two clubs' Champions League games last season, although this season's group match in Manchester in October passed off peacefully.
Eighteen United fans needed hospital treatment in April after clashes on the terraces in Rome and outside the ground.
Italian police were accused by United club officials of handing out "indiscriminate beatings" as they charged United supporters with batons.
Violence flared again a week later at the return leg at Old Trafford when scuffles broke out outside the ground.
A volley of missiles was thrown at Roma supporters as they entered the away end turnstiles and 21 people, including 14 United fans, were arrested.
United boss Sir Alex Ferguson had hoped Wednesday's game would pass off peacefully but the British Embassy in Rome had warned supporters faced a "real danger of attack" by the Ultras.
The 1,200 British supporters who made the journey were largely shepherded into the stadium two hours before kick-off, with clear segregation in place in the less than capacity crowd.
Greater Manchester Police officers travelled to Rome and before the game warned hooligans not to attend.
They liaised with their colleagues in Italy to identify any known or potential troublemakers.
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