The defender was part of the Scottish side given a footballing lesson by Spain in midweek as Craig Levein's side narrowly missed out of the play-offs.
Berra knows it will be a different kind of challenge at the Hawthorns with local pride at stake but is aware points are vital to both sides after poor starts to the campaign.
He said: "This will be a completely different game from the Spain one. Scotland were always going to be underdogs against Spain. As a defender, it certainly gives you a different view of the game to line up against the world and European champions.
"It's a totally different challenge to the British game with the front five or six guys very small and skilful. I think I only had to head the ball once in normal play!
"Now I've got the derby and the Premier League is already completely different to international football and this will be a real skelter game."