Sale Sharks face the daunting prospect of meeting European champions Munster and two French teams in the group stages of next season's Heineken Cup.
The Guinness Premiership side were handed arguably the toughest task of all the English clubs in Tuesday morning's draw, with the talented Clermont Auvergne and Montauban awaiting them in Pool One.
Premiership champions Wasps must also overcome a strong trio if they are to reach the knockout stages, with Leinster, Castres and Edinburgh making up Pool Two.
Runners-up Leicester were drawn against Perpignan, Welsh entertainers Ospreys and Italian minnows Treviso in Pool Three.
This season's defeated Heineken Cup finalists Toulouse are in Pool Five alongside Challenge Cup winners Bath, Newport Gwent Dragons and Glasgow.
In Pool Six, Gloucester appear to have a strong chance of qualifying from a group which also includes French side Biarritz, cup quarter-finalists Cardiff and Italy's Calvisano.
Harlequins' prospects look slightly less rosy in Pool Four, however, with Stade Francais, Llanelli Scarlets and Ulster awaiting them when the matches get under way in October.
Tuesday's draw was the first to use the new European Cup Rugby rankings system which split the clubs into four tiers based on performances in the competition over the last four seasons.
Full Draw:
POOL ONE
Munster
Sale
Clermont Auvergne
Montauban
POOL TWO
Wasps
Leinster
Castres
Edinburgh
POOL THREE
Leicester
Perpignan
Ospreys
Treviso
POOL FOUR
Stade Francais
Llanelli
Ulster
Harlequins
POOL FIVE
Toulouse
Bath
Newport Gwent Dragons
Glasgow
POOL SIX
Biarritz
Gloucester
Cardiff
Calvisano
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