Europa League - Athletic set up United clash
Ten-man Athletic Bilbao beat Lokomotiv Moscow 1-0 to reach the Europa League last 16 as Steaua Bucharest's dream of playing the final in their home city ended at Twente Enschede.
Atletico Madrid beat Lazio 1-0 to complete a 4-1 aggregate win and Valencia, while Steaua's run ended at Twente Enschede, who were joined in the last 16 by fellow Dutch side PSV Eindhoven, after a 4-1 demolition of 10-man Trabzonspor. Udinese progressed with a 3-0 win at PAOK Salonika.
Athletic struggled to claw back a 2-1 first leg deficit against Lokomotiv and their cause appeared to be lost when Fernando Amorebieta was given a second yellow card for a trip of Roman Shishkin on the hour.
Yet, two minutes later, teenager Iker Muniain scored at the far post to send Athletic through on away goals.
Former European champions Steaua were already trailing 1-0 as they travelled to Twente and their hopes ended just before the half hour following a blunder by Ciprian Tatarusanu, who lost his footing as he tried to control a back pass.
Luuk de Jong pounced before squaring to Nacer Chadli, who calmly rolled into the unguarded net to give Twente another 1-0 win.
Braga, last season's runners-up, followed fellow Portuguese and defending champions Porto out of the tournament as they lost 2-1 on aggregate to Besiktas, despite winning the second leg 1-0 away with a Lima goal.
Uruguayan defender Diego Godin headed the winner for Atletico Madrid, who chalked up their sixth successive home win in Europe and remained unbeaten after nine games under coach Diego Simeone, the former Argentine international.
Metalist Kharkiv chalked up the biggest win, thumping Salzburg 4-1 for an 8-0 aggregate win.
Porto were eliminated by Manchester City on Tuesday.
Hanover 96 won 1-0 at Bruges to complete a 3-1 aggregate win while Standard Liege also went through despite a goalless draw at home to Wisla Krakow who had Gervasio Nunez sent off for a second bookable offence just after the hour. The Belgians won on away goals.