All the team news for Wednesday's Premier League games, with Liverpool and Manchester United facing defensive injury crises.

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• Burnley v Manchester United
• Hull City v Tottenham Hotspur
• Birmingham City v Portsmouth
• Liverpool v Stoke City

Premier League team news (kick-offs 19:45 unless stated)

Burnley v Manchester United

The Clarets are without captain Steven Caldwell, who has not recovered from a groin injury, while Michael Duff is also out. Andre Bikey, recently signed from Reading, is eligible to make his debut at centre-back, while David Edgar could also debut after serving a suspension picked up when at Newcastle.

United are missing a host of defenders, with Rio Ferdinand, Nemanja Vidic, Jonny Evans, Gary Neville and Rafael all set to miss the game. That could mean a return for Wes Brown, who should partner John O'Shea in the centre of defence. Michael Carrick should make his first appearance of the season, while Anderson and Ryan Giggs are also pushing to start after missing out on Sunday.

Hull City v Tottenham

Hull have been rocked by the news that captain Ian Ashbee could miss the rest of the season with a knee injury. Dean Marney is also out after picking up an injury against Chelsea on Saturday. Geovanni and Nick Barmby are the most likely contenders to replace the attacking midfielder.

Ledley King's fragile knees prevent him playing more than once per week, so he will drop out, with Vedran Corluka shifting to centre-back and Kyle Naughton likely to make his first start at right-back. Spurs will be otherwise unchanged unless Harry Redknapp chooses to shuffle his forward line to accommodate Peter Crouch.

Birmingham v Portsmouth

Christian Benitez should start after his promising cameo at Manchester United on Sunday; he could replace Cameron Jerome up front unless Alex McLeish opts to play two strikers. Lee Bowyer is still suspended while Giovanny Espinoza is expected to miss out injured.

Pompey have still not received international clearance for Belgian full-back Anthony Vanden Borre and could line up unchanged. Steve Finnan and Hermann Hreidarsson are still out injured.

Liverpool v Stoke City (20:00)

Martin Skrtel's cracked jaw could mean a start for little-known Spanish defender Daniel Sanchez Ayala (pictured), with Daniel Agger still struggling with a back injury. Skrtel trained on Tuesday but is unlikely to be risked. Emiliano Insua continues at left-back. In midfield, Yossi Benayoun may replace Ryan Babel, who was ineffective against Tottenham.

Dave Kitson, Glenn Whelan, Danny Pugh and Carl Dickinson are all available for Stoke after injury, but Tony Pulis may stick with the side that beat Burnley on Saturday. Rafa Benitez will keep a particularly close eye on Stoke defender Ryan Shawcross, who has been linked with a £6m move to Anfield.

Follow LIVE coverage of all four Premier League games; click the links under the photo for predicted line-ups and match facts.