Euro 2012 - Walker, Van der Vaart injured
Tottenham full-back Kyle Walker has become the fourth player to withdraw from the England squad for the friendly against Holland at Wembley.
Twenty-one players from Stuart Pearce's original squad have reported to the team hotel as planned for Wednesday's international match, but Walker joins Wayne Rooney, Tom Cleverley and Darren Bent on the sidelines.
Walker played the full 90 minutes for Tottenham in their 5-2 defeat against Arsenal in Sunday's North London derby.
The FA did not specify the nature of Walker's injury, but confirmed on their website that there are no plans at present to call up a replacement for the 21-year-old or any of his fellow absentees.
Following the ankle injury Bent suffered in Aston Villa's goalless draw with Wigan on Saturday, Manchester United pair Rooney and Cleverley were sidelined on Sunday.
Neither man was able to play for the Premier League champions in their win over Norwich at Carrow Road. Rooney has not recovered from a throat infection and Cleverley has an ankle injury.
"Very disappointed not to be joining up with the England squad tonight," said Cleverley on Twitter. "And again, it isn't a recurrence of the injury, it's the other leg."
It continues the spate of bad luck Cleverley has endured with the senior squad. He was earmarked to make his debut in the August friendly against Holland only for the match to be called off due to the London riots.
After not being used in the Euro 2012 qualifiers against Bulgaria and Wales in September, Cleverley has not been fit since but just one game after his return from injury this month, was selected by Pearce and had been tipped to play in the rearranged game against the Dutch this week.
That will not happen now, leaving the 23-year-old just two games - against Norway and Belgium - to make his mark before the final Euro 2012 squad has to be submitted.
Pearce opted not to make any official announcement about his squad on Sunday evening. However, with both Rooney and Bent missing, he is left with just Danny Welbeck, Daniel Sturridge and Fraizer Campbell from the strikers he originally selected.
That chronic shortage of numbers will surely trigger at least one replacement, although Pearce does have the option of selecting Steven Gerrard or Ashley Young in advanced attacking roles.
The alternatives would be to draft in additional bodies, with Liverpool's Andy Carroll a more likely alternative that Peter Crouch, who scored for Stoke in their win over Swansea, and Jermain Defoe given the relatively youthful nature of his squad.
Tottenham playmarker Rafa van der Vaart has been ruled out for Holland with an ankle injury.
The Dutchman appeared as a second-half substitute against Arsenal, but after linking up with the national squad it was decided that the injury will cost him his place.
Bert van Marwijk has decided against calling up a replacement, leaving him 22 available players for the friendly.