Leeds manager Dennis Wise will join Newcastle's coaching staff after the two clubs agreed a compensation fee.
The 41-year-old will depart Elland Road on Tuesday after preparing the side for their Coca-Cola League One clash at Southend.
A club statement read: "We have agreed a compensation package with Newcastle for the services of our manager Dennis Wise and he will part company with the club on Tuesday, after completing the preparations for our game at Southend that evening.
"Newcastle had approached us for permission to speak with Dennis on Friday and since then things have happened very quickly.
"We will always be grateful to Dennis for the way he has turned things around at the club on the playing side and he goes with our best wishes for the future.
"We are not prepared to comment on the inevitable speculation that will now follow about who will replace Dennis. That is not the way we do our business at this club.''
Wise has been offered a reported £1million-a-year salary to become Newcastle manager Kevin Keegan's shock first signing since replacing Sam Allardyce as manager on January 16.
Neither Leeds nor Newcastle have confirmed what Wise's role will be at St James' Park, but it has been reported he is to operate as director of football.
Although Wise will prepare Leeds for Tuesday night's clash at Southend, the former Chelsea midfielder is not expected to attend the match.
His departure will stun Leeds fans, who had slowly begun to accept Wise as one of their own following his flying start to the season in Coca-Cola League One.
Leeds chairman Ken Bates, close friend and godfather to one of Wise's children, has already lost former assistant boss Gus Poyet to Tottenham earlier in the campaign and fans will view the manager's departure as a hammer blow to the club's bid to bounce straight back to the Championship.
The former Chelsea chairman convinced Wise he was the right man to lead the fallen Yorkshire giants back to the top flight in October 2006.
Wise and Poyet could not halt Leeds' slide into League One at the end of last season, but made a dream start to the current campaign.
Leeds were hit by a 15-point deduction by the Football League for breaking competition rules on administration, but won their first five matches and are challenging for automatic promotion.
Wise has recently drafted in four new permanent signings at Leeds, who could climb to second place with victory at Southend.
DENNIS WISE FACTFILE
1966: Born London, December 16.
1985: Joins Wimbledon on a free transfer. Makes his debut under Dave Bassett.
1986: Wimbledon win promotion to the old First Division.
1986-87: Scores four goals in 27 starts as Wimbledon stagger the critics by finishing sixth in the table in their first season in the top flight.
1988: Plays a key role in Wimbledon's amazing 1-0 FA Cup final triumph over Liverpool at Wembley.
1990: Signs for Chelsea in £1.6million move. Scores 13 goals in 44 games in first season as his side finish in the top half of the table but serves two spells of suspension. Awarded his first full England cap against Turkey and scores only goal of the game.
1994: Chelsea manager Glenn Hoddle strips Wise of the captaincy after he is sent off for foul and abusive language at Newcastle.
1995: Wise is jailed for three months for an assault on a taxi driver, although he is later acquitted on appeal.
1996: Misses selection for Euro 96.
1997: Leads Chelsea to victory in the FA Cup final.
1998: Chelsea capture League Cup and European Cup Winners' Cup under Wise's captaincy but Wise is passed over by Glenn Hoddle for World Cup squad.
1999: April - Wise is charged with biting the arm of Real Mallorca defender Elena Marcelino in the second half of Cup Winners' Cup semi-final first-leg 1-1 draw at Stamford Bridge. He is later cleared by UEFA.
September - Tackles Kurdish protester during Champions League match with Galatasaray.
October - Earns recall to England squad for friendly against Belgium.
2000: February - Charged with misconduct by the FA following an alleged confrontation in the tunnel after the 3-1 defeat of Wimbledon at Stamford Bridge.
April 13 - Fined £7,500 by FA for his part in tunnel bust-up.
April 29 - Makes 400th appearance for Chelsea in 2-0 victory over Liverpool.
May 20 - Lifts FA Cup - accompanied by baby son Henry - following 1-0 win over Aston Villa at Wembley.
May 31 - Named in England squad for Euro 2000.
July - Signs one-year extension to Chelsea contract, with the club indicating they will reward him with a coaching position at the end of his deal.
2001: June - Chelsea accept £1.6million bid from Leicester for Wise.
2002: May - Leicester relegated to Nationwide League at end of season.
July - Sent home from Leicester's Finland pre-season training camp after a "breach of club discipline" when he breaks the jaw of team-mate Callum Davidson.
August - Leicester terminate Wise's contract but an independent disciplinary commission rules they were not allowed to do so.
September 3 - Leicester take case to the High Court.
September 18 - Leicester win the right to sack Wise.
September 24 - Wise joins Millwall on a two-season deal.
October 16 - Appointed caretaker player-manager, with Wilkins as his assistant, following the departure of Mark McGhee.
October 18 - Sent off - the 13th red card of his career - just four minutes after bringing himself on against Sheffield United for two-footed lunge at Chris Armstrong.
November - Appointed Millwall player-manager until the end of the 2004-05 season.
2004: February - Charged with abusive behaviour by the FA after launching a tirade at referee Frazer Stretton following a 2-1 defeat at Sheffield United which was marred by a mass brawl.
April 4 - Millwall beat Sunderland 1-0 at Old Trafford, with Wise playing, to reach the FA Cup final for the first time in their history.
April 14 - Fined £3,000 and warned as to his future conduct by FA for his abuse towards referee Frazer Stretton in February.
May - Wise's Millwall lose 3-0 to Manchester United in the FA Cup final at the Millennium Stadium, gaining European qualification.
2005: May 8 - Millwall finish 10th in the Coca-Cola Championship and Wise steps down as manager following a meeting with new club chairman Jeff Burnige.
June - Joins Southampton on a free transfer and takes over as joint caretaker manager with Dave Bassett.
December - Leaves Southampton following the appointment of George Burley.
2006: January - Joins Coventry on pay-as-you-play deal.
May - Appointed Swindon manager with Gustavo Poyet as his assistant.
October 24 - Confirmed as new manager of Leeds.
2007: February 9 - Denies a Football Association charge of improper conduct after being ordered to leave the technical area during Leeds' Coca-Cola Championship defeat by West Brom at Elland Road on January 20.
May - Relegated to League One, finishing bottom of the table with 36 points.
2008: January 3 - Interviewed by police after he chased a youth who allegedly threw stones at his family car on New Year's Day.
January 28 - It is confirmed he will join Kevin Keegan's backroom team at Newcastle.
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