Roma captain Francesco Totti will miss Champions League game against Manchester United with a thigh injury.

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"At the end of yesterday's encounter, Francesco Totti complained of a pain in the flexor of his left thigh," the club said after the 1-1 Serie A draw at Cagliari in which the striker scored.

"In the morning of Sunday March 30 he was subjected to tests that highlighted a muscular injury in the cavity of the left thigh flexor. The player will have to have a period of rest and the situation will be monitored over the next few days."

Totti's loss is a big blow to Italy's sole Champions League survivor. He is their top scorer in Serie A this term with 14 goals and he picked up the European Golden Boot last season with 26 league strikes.