United are without 10 members of their first-team squad, including captain Nemanja Vidic who is out for the season, ahead of their trip to Queens Park Rangers on Sunday.
Arsenal are also running into problems. Defender Andre Santos is out for three months, leaving the Gunners without any recognised full-backs ahead of their visit to Manchester City.
The home side at Etihad Stadium will also be light in defence as, with Aleksandar Kolarov already ruled out due to injury, City have lost Gael Clichy to suspension ahead of the match against his former side.
Micah Richards is also a doubt for Roberto Mancini's side.