The club have already seen Jack Wilshere ruled out for the season, and Euro 2012, while Abou Diaby is still on the sidelines due to a knee injury.
With youngster Francis Coquelin still sidelined with a hamstring problem, the last thing Arsenal needed was Thursday's news that Mikel Arteta will miss the remainder of the campaign with an ankle ligament injury.
He is likely to be replaced in the team by Aaron Ramsey, but a further complication arises with the fact Yossi Benayoun is ineligible to play under the conditions of his loan move from Chelsea.
That means Gervinho or Alex Oxlade-Chamberlain will come into the starting line-up against a Chelsea side full of confidence following a Champions League win over Barcelona.
For a full round-up of the weekend's injuries and suspensions, have a look at the table below.