Match of the weekend: Chelsea v Tottenham
Tottenham's great start to the new season stuttered last weekend but against Chelsea on Sunday they have the chance to get right back on track.
Like the game with Manchester United, the Chelsea clash will be a real test of Spurs' ability to mix it with the big boys.
Last week, they failed as they allowed United to dominate the game at White Hart Lane, but if Harry Redknapp's side can hold their own at Stamford Bridge, they can put the result against the champions down as a blip.
The intense rivalry between these two clubs already makes this a mouth-watering fixture, but with Spurs finding themselves at the business end of the table this so far this season, there is sure to be an added edge. The atmosphere at the Bridge promises to be special.
You would have put your house on a Chelsea win this time last year, but with Harry in charge of Spurs and working wonders, anything is possible. It will certainly be interesting to see if they have what it takes to respond positively to defeat.
Upset of the weekend: Manchester United v Manchester City
After their heavy investment over the summer, City have a real chance of going to Old Trafford and taking the honours in the first Manchester derby of the season.
Off the back of last week's game at Arsenal, this clash will provide Mark Hughes with a further barometer of how far his side has come since adding so much talent to their squad over the summer.
Of course, City have recent pedigree at Old Trafford - they won there the season before last - and their form so far this season suggest they are capable of upsetting the champions.
They will be missing Emmanuel Adebayor, their top scorer, but Craig Bellamy played well enough against Arsenal to suggest he can fill the Togo striker's boots. And if Carlos Tevez plays, well, who knows?
Player to watch: Carlos Tevez
Indeed, look no further than the Argentina striker for this weekend's player to watch.
It's going to be interesting to see how he performs against his former club, considering the pressure he will be under.
He expects a warm reception from his former fans, but I'm not so sure. It won't be as bad as Arsenal fans' reaction to Adebayor last weekend, but he won't be welcomed with open arms either.
West Ham fans have always reserved a special place in their hearts for Tevez and they cheered his name when he appeared against them for United. But he has generally struggled to perform when faced with his former club, so it will be interesting to see how he reacts with the tables turned.
The Adebayor situation has only increased the pressure on his shoulders and it could turn out to be a difficult day for him. But if he shows the same kind of commitment he displayed during his time at United, he may yet prove to be a thorn in his former club's side.
Under pressure: Paul Hart
Defeat for Portsmouth at Aston Villa on Saturday and Pompey will have gathered a grand total of zero points from their opening six games this season.
At the moment, Hart is not in control of his team and the club's financial troubles are having a real impact on the pitch.
He has managed to sign new players but they are nowhere near the quality he would have liked, Danny Webber being the most recent and clearest example.
The pressure to win points may never have been greater, yet Hart's job appears to be safe, ironically thanks to the very same problems which put Pompey in this position in the first place.
With no money at the club, it would be difficult to replace Hart with a boss of a certain calibre, but even with a bit of continuity in the managerial hot seat, already the Championship beckons for Pompey next season.