Match of the weekend: Manchester United v Arsenal
This is obviously the stand-out fixture of the weekend. There have been plenty of classic matches between the two sides, and this could be an encounter to savour.
United have been typically slow to get out of the blocks. The season has just kicked off and they have lacked their usual energy, pace and creativity. They will hope the last 40 minutes against Wigan, when they tore them apart, have helped them slip into top gear.
Arsenal are off to a flier, but the absence of Cesc Fabregas is a real blow for them. They have made a great start, but as ever there are questions about their durability.
However, if they stay true to their philosophy and have areal go at United they could get a result.
Sir Alex Ferguson has a problem in midfield, where he might need to play all three of Darren Fletcher, Anderson and Park Ji-Sung to combat Arsenal's energy and endeavour, but that would leave United short of options out wide. It should be fascinating.
Upset of the weekend: Portsmouth v Manchester City
It really would be a surprise if Portsmouth pulled this off - they look as bad as any Premier League side I have seen for a long time, while City have made a solid start and have not yet conceded a goal.
So why do I think there might be a shock? Mark Hughes has filled his side with players who love the big stage, but I am not sure they will be so comfortable at Fratton Park, which is one of the few remaining grounds where the crowd make a big difference.
The first goal will be crucial - if City get it, I can't see them surrendering their lead. But if Portsmouth go in front, they might just upset their millionaire visitors' equilibrium enough to sneak a result.
Player to watch: Jozy Altidore, Hull City
Phil Brown's approach to transfers might seem scattergun at times, but he seems to have found a real gem, signed on loan from Villarreal.
He set up a goal 30 seconds into his debut and scored against Southend on Tuesday; he is a real handful, and looks like a typical American player in that he has outstanding work rate and determination.
Of course he still has plenty to prove and he can start against Wolves. The lack of a consistent front man was a big reason behind their collapse last season - if Altidore keeps firing things could be easier this time around.
Under pressure: Gary Megson and Rafa Benitez
There will be plenty of bitten nails and hoarse voices when Bolton play Liverpool at the Reebok Stadium.
Megson's Bolton were booed off last week against Hull, and must avoid defeat to get the fans off their backs and register their first point of the season.
Two defeats in the first three have left Liverpool bereft of confidence and more importantly points.
They have really missed the midfield linking play of Xabi Alonso and do not look a happy side, constantly arguing with officials when things go against them.
With leaders Chelsea expected to win at home to Burnley, even a draw would leave Liverpool eight points off the top on Saturday night. Not an insurmountable lead at this early stage, of course, but hardly the start Benitez would have wanted.
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