Match of the weekend: West Ham United v Manchester United
Despite United's exemplary recent record in the league - they have scored 10 without reply over the course of their last three league meetings - they were hammered 4-0 when they visited Upton Park back in November.
That was a Carling Cup fixture, and United fielded a particularly weakened side, but they will travel to East London on Saturday with lots of injuries in defence and with one eye on their European meeting with Chelsea on Wednesday.
West Ham have really got their act together in the last few weeks, losing just one of their last seven. Since Thomas Hitzelsperger finally got fit and Demba Ba arrived on loan, they look a very different proposition going forward. They can go into this game believing it is one they can win.
I'm not sure how much importance should be placed on Scott Parker and Wayne Rooney being rested from the second part of their international duties, but it certainly can't do them any harm.
I still expect United to come through this one, but the Hammers should certainly make it a great game to watch.
Upset of the Weekend: Wigan Athletic v Tottenham Hotspur
The match at the DW is poised similarly to the one at Upton Park. Spurs travel halfway up the country to face a struggling team which has already beaten them this season and with plenty of important players not making the journey.
The difference here is that Spurs, by a quirk of the fixture list, kick-off slightly later than United and play their Champions League fixture a day before them. That piece of scheduling is even harsher when you consider that Harry Redknapp has to take his side to Spain, while United's match is only in London.
Redknapp will be a lot more reticent to risk his best players in this game, particularly with star man Gareth Bale already a doubt for the meeting with Real Madrid.
Equally, he will be more than a little troubled by the fact that they have only taken two points from the last nine available to them, all against sides battling relegation.
Wigan have shown on occasions that they are capable of playing the attractive, passing game that Roberto Martinez strives for, but they have simply not clicked often enough, and that is why they find themselves bottom of the table.
However, time and again this season we have seen sides in the lower reaches of the table come up trumps against the big teams, and with Tottenham's minds occupied with one of the biggest matches in their history, the Latics may just be able to take advantage if they can find that cutting edge which is so often lacking.
Under pressure: Steve Kean (Arsenal v Blackburn Rovers)
After the initial 'bounce effect' which so often comes with a new manager, Kean is beginning to understand just what a great job Sam Allardyce was doing at Blackburn.
Without a win in their last six in the league, Rovers have plummeted down the table, and are now just a point off the bottom three despite sitting in 13th.
So it is not the ideal time to make the trip down to the emirates Stadium, particularly to face an Arsenal side who have just got Cesc Fabregas, Theo Walcott and Alex Song back fit and Robin van Persie over an injury scare.
Rovers have not won away at Arsenal in nigh on a decade, when Edu scored at both ends and Dwight Yorke hit the winner, back in 2002.
Blackburn's owners have had to come out and publicly back their man. Considering he is only in his fourth month in the job, that is not a good sign.
Player to watch: Ashley Young (Everton v Aston Villa)
Young has quite rightly been the one to have hogged most of the plaudits following two quality displays for England over the past week.
However, playing well against Wales and then in a friendly does not all of a sudden make you a top player. That is not how it works.
The media have been keen to latch on to Young because his contract is running down at Villa, so they can rehash all the old reports linking him with the top clubs.
But if he wants to prove that he deserves such a move, he needs to play like that from now until the end of the season. Villa need him on song to drag them clear of the relegation mire.
He has two choices: play for himself, as he usually seems to do, or really make the effort and fight for his team. There are fewer grounds in the Premier League where a team's unity and common purpose is tested more than at Goodison Park.
If Young can help his side get a victory at Everton, that could spark a run of results in upcoming fixtures against Newcastle, West Ham, Stoke and West Brom. If he has done his bit, then the final two games of the season against Arsenal and Liverpool will not be the do-or-die clashes they threaten to be.