GAME OF THE WEEKEND: Arsenal v Manchester United
We have seen time and again in recent years that when Arsenal play United in the important games at the business end of the season, they always blow it. They have not beaten United in the second half of a season since January 2007.
However, this fixture remains one of the biggest in the Premier League, and the Gunners can still make United's task of winning a record 19th title that bit harder by getting a result at the Emirates on Sunday.
To do so, they will have to find a way of stopping Wayne Rooney. The England striker has hit a rich vein of form, thriving on his freedom to drop deep and play in team-mates, most notably Javier Hernandez.
That makes Alex Song a key man for them. The Cameroon midfielder needs to be disciplined and track Rooney whenever United have the ball. Arsenal may be playing at home, but Song should leave the attacking contributions to Cesc Fabregas and co and just focus on denying Rooney space between him and Arsenal's brittle defence.
Of course, United have plenty of other players who can hurt them. While Schalke simply did not turn up in their Champions League meeting in midweek, the Red Devils had plenty of players who look to have found their most lethal form at just the right time.
Arsene Wenger will be all too aware that even third place is not assured yet, and a win over United could have big implications for the start of next season as well as the end of this.
If the Gunners lose yet another big game, then perhaps disbelief will creep into the minds of some of his star players, who may finally concede that they will have to look elsewhere if they are to claim winner's medals. Equally, a third defeat to United this season may convince Wenger that sweeping changes are needed to try and move the club forward next term.
Their title hopes may be little more than a mathematical possibility now, but there is still a lot riding on this game for the Gunners.
UPSET OF THE WEEKEND: Chelsea v Tottenham Hotspur
This fixture is the other key component in the title race, and a defeat for Chelsea would all but hand the title to United. Winning at Stamford Bridge, however, is something Tottenham have not done since 1990.
Chelsea have won seven of their last eight league games, while Spurs have won just two in the same period, so it would be a real upset if that 21-year run was not preserved.
However, it does remain a possibility, with Tottenham due a win and desperate to catch Manchester City and return to the Champions League. They also have Liverpool breathing down their necks as they go in search of a Europa League place.
Chelsea will of course be heavy favourites, but an away win would have huge consequences for the all of the teams in the top half still with something to play for.
UNDER PRESSURE: Steve Kean (Blackburn Rovers v Bolton Wanderers)
When you look at the clubs still fighting relegation, Blackburn are one of the teams you really struggle to make a case for them staying up.
They haven't won a game since January and have only scored once in their last four games. Against City they offered very little up front, and with Ryan Nelsen out for the season they are not even a solid side defensively.
Defeat to a Bolton side coming off the back of a morale-boosting win against Arsenal and a couple of other results not going their way would leave them in the bottom three, and the wisdom of hiring Steve Kean will come under even greater scrutiny.
After this Lancashire derby game they will travel to fellow strugglers West Ham and Wolves, either side of welcoming Manchester United to Ewood Park.
It is a truly challenging trio of fixtures for which you would ideally have an experienced and canny manager who would get the team organised and drilled into getting the vital results any way they could.
Who was it that Venky's sacked and replaced with Kean again?
PLAYER TO WATCH: Edin Dzeko (Manchester City v West Ham United)
Dzeko's Premier League goal drought got nowhere near the amount of coverage as Fernando Torres's did, but the Bosnian also finally got off the mark in the last round of games.
Because his fee (while huge in itself) was dwarfed by that which Torres moved for, he was not an established star in Britain to begin with and he had at least scored in the FA Cup and in Europe, his winner against Blackburn on Monday passed largely without comment. In fact, the person who talked about it most was Roberto Mancini.
The irony is that Mancini's insistence on playing a system that does not play to Dzeko's strengths is what has hampered the striker's progress at City. Imagine a strike force of Dzeko and Carlos Tevez, with two proper wide men, unleashed on the Premier League and in Europe next season. That is a front pairing that most clubs in Europe would love to have.
It is a shame that Tevez is injured at the moment, because this season run-in would be the ideal time for Mancini to try out that pairing, ready for next season.
But, in the meantime, the Bosnian should have the chance to get on the scoresheet again against a West Ham side missing Scott Parker and Mark Noble, and help fire City towards the Champions League.