| Pos. | Player | Goals | Team |
|---|---|---|---|
| 1 | Luis Suarez | 35 | Ajax |
| 2 | Bryan Ruiz | 24 | (FC) Twente |
| 3 | Mads Junker | 23 | Roda JC Kerkrade |
| 4 | Mounir El Hamdaoui | 20 | AZ Alkmaar |
| 5 | Marko Pantelic | 16 | Ajax |
| 6 | Bas Dost | 15 | Heracles Almelo |
| 7 | Everton | 14 | Heracles Almelo |
| 7 | Balázs Dzsudzsák | 14 | PSV |
| 7 | Tim Matavz | 14 | (FC) Groningen |
| 10 | Ola Toivonen | 13 | PSV |
| 11 | Jeremain Lens | 12 | AZ Alkmaar |
| 11 | Blaise Nkufo | 12 | (FC) Twente |
| 13 | Danny Koevermans | 11 | PSV |
| 13 | Otman Bakkal | 11 | PSV |
| 13 | Jon Dahl Tomasson | 11 | Feyenoord |
| 13 | Gerald Sibon | 11 | sc Heerenveen |
| 13 | Ricky van Wolfswinkel | 11 | (FC) Utrecht |
| 18 | Rydell Poepon | 10 | Sparta Rotterdam |
| 18 | Erik Falkenburg | 10 | Sparta Rotterdam |
| 18 | Siem de Jong | 10 | Ajax |
| 18 | Miroslav Stoch | 10 | (FC) Twente |
| 18 | Jacob Mulenga | 10 | (FC) Utrecht |
| 23 | Matthew Amoah | 9 | NAC Breda |
| 23 | Sandro Calabro | 9 | VVV-Venlo |
| 23 | Willem Janssen | 9 | Roda JC Kerkrade |
| 26 | Björn Vleminckx | 8 | NEC |
| 27 | Anthony Lurling | 7 | NAC Breda |
| 27 | Michal Papadopulos | 7 | sc Heerenveen |
| 27 | Lasse Nilsson | 7 | Vitesse |
| 27 | Frank Demouge | 7 | Willem II |
| 27 | Willie Overtoom | 7 | Heracles Almelo |
| 27 | Demy de Zeeuw | 7 | Ajax |
| 27 | Derk Boerrigter | 7 | RKC Waalwijk |
| 27 | Dries Mertens | 7 | (FC) Utrecht |
| 27 | Wesley Verhoek | 7 | ADO Den Haag |
| 27 | Santi Kolk | 7 | Vitesse |
| 27 | Roy Makaay | 7 | Feyenoord |
| 38 | Dennis Rommedahl | 6 | Ajax |
| 38 | Andreas Granqvist | 6 | (FC) Groningen |
| 38 | Gregory van der Wiel | 6 | Ajax |
| 38 | Keisuke Honda | 6 | VVV-Venlo |
| 38 | Kees Kwakman | 6 | NAC Breda |
| 38 | Edwin de Graaf | 6 | NAC Breda |
| 38 | Thomas Enevoldsen | 6 | (FC) Groningen |
| 38 | Charlison Benschop | 6 | RKC Waalwijk |
| 38 | Saďd Boutahar | 6 | Willem II |
| 38 | Darl Douglas | 6 | Heracles Almelo |
| 38 | Boldizsár Bodor | 6 | Roda JC Kerkrade |
| 44 | Christophe Grégoire | 5 | Willem II |
| 45 | Sekou Cissé | 5 | Feyenoord |
| 45 | Nicklas Pedersen | 5 | (FC) Groningen |
| 46 | Viktor Elm | 5 | sc Heerenveen |
| 47 | Maarten Martens | 5 | AZ Alkmaar |
| 48 | Urby Emanuelson | 5 | Ajax |
| 49 | Danko Lazovic | 5 | PSV |
| 49 | Kenneth Perez | 5 | (FC) Twente |
| 49 | Ibrahim Afellay | 4 | PSV |