| Pos. | Player | Goals | Team |
|---|---|---|---|
| 1 | Diego Forlán | 32 | Atletico Madrid |
| 2 | Samuel Eto'o | 30 | Barcelona |
| 3 | David Villa | 28 | Valencia |
| 4 | Lionel Messi | 23 | Barcelona |
| 5 | Gonzalo Higuaín | 22 | Real Madrid |
| 6 | Thierry Henry | 19 | Barcelona |
| 6 | Álvaro Negredo | 19 | U.D Almeria |
| 8 | Frederic Kanouté | 18 | Sevilla |
| 8 | González Raúl | 18 | Real Madrid |
| 10 | Sergio Aguero | 17 | Atletico Madrid |
| 11 | Joseba Llorente | 15 | Villarreal |
| 12 | Fernando Llorente | 13 | Athletic Bilbao |
| 12 | Roberto Soldado | 13 | Getafe C.F |
| 12 | Nikola Zigic | 13 | Racing Santander |
| 15 | José Javier Barkero | 12 | Numancia |
| 15 | Mate Bilic | 12 | Sporting of Gijón |
| 15 | Giuseppe Rossi | 12 | Villarreal |
| 18 | Aritz Aduriz | 11 | RCD Mallorca |
| 18 | Achille Emana | 11 | Real Betis Balompié |
| 18 | Juan Mata | 11 | Valencia |
| 18 | Walter Pandiani | 11 | Osasuna |
| 22 | David Barral | 10 | Sporting of Gijón |
| 22 | Javier Camuñas | 10 | Recreativo Huelva |
| 22 | Henok Goitom | 10 | Valladolid |
| 25 | Colunga Pérez Adrián | 9 | Recreativo Huelva |
| 25 | Antonio Galdeano Apoño | 9 | Málaga |
| 25 | Nabil Baha | 9 | Málaga |
| 25 | Sergio García | 9 | Real Betis Balompié |
| 25 | Jose Manuel Jurado | 9 | RCD Mallorca |
| 25 | Javad Nekounam | 9 | Osasuna |
| 31 | Juan Arango | 8 | RCD Mallorca |
| 31 | Santi Cazorla | 8 | Villarreal |
| 31 | Klaas Jan Huntelaar | 8 | Real Madrid |
| 31 | Ángel Lafita | 8 | Deportivo La Coruna |
| 31 | Clemente Luis Fabiano | 8 | Sevilla |
| 31 | Albert Luque | 8 | Málaga |
| 31 | Dirnei Renato | 8 | Sevilla |
| 31 | Kalu Uche | 8 | U.D Almeria |
| 39 | Juan Albín | 7 | Getafe C.F |
| 39 | Dos Santos Eliseu Pereira | 7 | Málaga |
| 39 | Arjen Robben | 7 | Real Madrid |
| 39 | Jonathan Sesma | 7 | Valladolid |
| 39 | Sabrosa Simao | 7 | Atletico Madrid |
| 39 | Mohamed Tchite | 7 | Racing Santander |
| 39 | Ikechukwu Uche | 7 | Getafe C.F |
| 39 | Joan Verdú | 7 | Deportivo La Coruna |
| 47 | Carlos Aranda | 6 | Numancia |
| 47 | Ruben García Cani | 6 | Villarreal |
| 47 | González Jiménez Carmelo | 6 | Sporting of Gijón |