The only giant-killings I foresee are: - Oldham v Everton - Middlesbrough v Brentford/Chelsea
The other ties against lower league oppositions are 'royal spanking' by their superior Premier League giants.
Could have been more interesting if Arsenal and Man City games are away from home. But you never know, Koscienly or Kompany can commit a crazy tackle resulting in sending off offence for their respective teams. ;)