Jets 24, Giants 21 (OT)
New York Jets quarterback Mark Sanchez left in the fourth quarter with a right shoulder injury and did not return as the Jets defeated the New York Giants 24-21 in overtime.
Sanchez took a big hit from Giants defensive end Marvin Austin and was in obvious pain and had his right (throwing) shoulder iced after the injury before heading to the locker room.
The Jets won on a Billy Cundiff 32-yard field goal.
Sanchez, who has been in a battle with rookie Geno Smith for the starting job, did not even enter the game until midway through the fourth quarter.
Smith had thrown three interceptions and ran out of the end zone for a safety.
Jets coach Rex Ryan tried to explain why he put Sanchez on the field when he already had locked up the starting job.
"We're just trying to win the game," Ryan said, adding that injuries are part of the game.
Sanchez completed five-of-six passes for 72 yards before the injury.
Smith completed 16-of-30 passes for 199 yards with a touchdown.
Ryan Spadola caught three passes for 110 yards for the Jets.
David Wilson ran for 92 yards, including an 84-yard touchdown run in the first quarter.
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Colts 27, Browns 6
Andrew Luck threw two touchdown passes as the Colts' starting offense continued to roll, defeating the Browns 27-6. Luck completed 16-of-25 passes for 164 yards for the Colts, who led 10-0 at halftime and 20-3 at the end of the third quarter.
Colts receiver T.Y. Hilton caught a touchdown pass for the third straight week.
Reggie Wayne caught seven passes for 79 yards and Griff Whalen pulled in four passes for 57 yards.
Browns quarterback Brandon Weeden completed 12-of-25 passes for 105 yards. Backup Jason Campbell connected on eight-of-14 passes for 112 yards.
The Colts, who allowed 44 points in their pre-season opener against Buffalo, allowed just 13 first downs and just a pair of field goals by the Browns.
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Eagles 31, Jaguars 24
Michael Vick was strong again as Philadelphia's starter in a 31-24 win over Jacksonville.
Vick completed 15-of-23 passes for 184 yards and ran seven times for 53 yards.
Vick's backup, Nick Foles, completed 10-of-11 passes for 112 yards.
Bryce Brown ran 11 times for 92 yards and a touchdown for the Eagles.
Chris Polk scored the winning touchdown on a four-yard run in the fourth quarter.
Chad Henne passed for 106 yards and two touchdowns and Jordan Todman ran for 105 yards and a score for the Jaguars.
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Buccaneers 17, Dolphins 16
Mike Glennon's 12-yard touchdown pass to David Douglas with just over a minute remaining was the difference for Tampa Bay as they prevailed 17-16 over Miami.
The Dolphins out-gained the Buccaneers 312 yards to 160 but could not manufacture a win.
Tampa Bay quarterback Josh Freeman completed just six-of-16 passes for 59 yards.
Ryan Tannehill completed 17-of-27 passes for 150 yards for the Dolphins.
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Cowboys 24, Bengals 18
Tony Romo threw touchdown passes of five yards to Dez Bryant and 12 yards to Miles Austin in the second quarter for the Cowboys to help Dallas to a 24-18 win over Cincinnati.
Romo completed 13-of-18 passes for 137 yards and rookie Joseph Randle added 66 yards on 16 carries for Dallas.
Andy Dalton connected on 12-of-16 passes for 113 yards and A.J. Green caught three passes for 42 yards for the Bengals.
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Broncos 27, Rams 26
Peyton Manning passed for 234 yards in one half, but it was the backups who rallied the Broncos past the Rams 27-26.
Denver trailed 20-10 at halftime but the Broncos' Lerentee McCray blocked a punt in the fourth quarter and Lance Ball cashed in with a five-yard go-ahead score.
St Louis' Kellen Clemens came back and found Zach Potter for a one-yard touchdown pass with two minutes remaining, but threw an incomplete pass on the two-point conversion attempt that would have given the Rams a late lead.
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Titans 27, Falcons 16
Jake Locker passed for 133 yards and a score to lead the Titans to a 27-16 win over Atlanta.
Nate Washington caught four passes for 70 yards and a touchdown and Chris Johnson ran for 65 yards on 11 carries for Tennessee.
The Titans sacked Atlanta quarterback Matt Ryan five times. Ryan connected on 11-of-19 passes for 138 yards.
Steven Jackson added 51 yards on 12 carries for the Falcons.
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Chiefs 26, Steelers 20 (OT)
Quarterbacks Ben Roethlisberger and Alex Smith threw their first touchdown passes and played well in their most extensive action of the pre-season as Smith's Chiefs beat Roethlisberger's Steelers 26-20 in overtime.
Rico Richardson caught a 15-yard touchdown pass from Chase Daniel with 8:53 left to end the contest.
Roethlisberger completed 13-of-19 passes for 106 yards and one touchdown. Smith was 17-of-24 for 158 yards and one score. Both played the entire first half along with the rest of the first-team offenses.
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Redskins 30, Bills 7
With starting quarterback Robert Griffin III and backup Kirk Cousins sidelined with injuries, reserves Rex Grossman and Pat White led the Washington Redskins to a 30-7 victory over the visiting Buffalo Bills.
Grossman, Washington's starter in 2011, led the Redskins on a 10-play, 86-yard scoring march on their first possession that included completions of 21 yards to running back Roy Helu and 31 to tight end Fred Davis before a seven-yard touchdown strike to receiver Pierre Garcon.
Kevin Kolb started in place of injured Bills rookie quarterback EJ Manuel and departed late in the first quarter with what were termed "concussion-like" symptoms.
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Chargers 24, Cardinals 7
Ryan Mathews rushed for 57 yards and a touchdown to give coach Mike McCoy his first pre-season victory with San Diego, a 24-7 result over Arizona.
It was not a good night for Arizona. Left guard Jonathan Cooper, the team's first-round draft pick in April, left the field in the third quarter with a left ankle injury.
Running back Rashard Mendenhall suffered an ankle injury after rushing for 47 yards on six carries. The Cardinals also had a punt and field goal attempt blocked and a fumble returned for a touchdown against them.
Cardinals quarterback Carson Palmer was 12-of-23 for 122 yards and threw a 16-yard touchdown pass to Michael Floyd in the third quarter.