Colts 34, Seahawks 28
Andrew Luck passed for 229 yards and two touchdowns and led another comeback victory as the Indianapolis Colts defeated the Seattle Seahawks.
The Colts trailed 28-23 in the final quarter where Luck led an 84-yard drive that put the Colts up for good.
T.Y. Hilton caught five passes for a career-high 140 yards and two touchdowns and Reggie Wayne had six catches for 65 yards for the Colts (4-1).
Russell Wilson passed for 210 yards and two touchdowns and rushed for 102 yards and Marshawn Lynch also had 102 rushing yards for the Seahawks (4-1).
Bengals 13, Patriots 6
The Cincinnati Bengals beat the Patriots, snapping quarterback Tom Brady's streak of 52 consecutive games with a touchdown pass in the process.
Running back BenJarvus Green-Ellis scored on a one-yard run on fourth-and-goal with 9:21 remaining to give Cincinnati a 13-3 advantage and the Bengals (3-2) defense kept New England (4-1) out of the end zone on three drives in the fourth quarter to get their first win against the Patriots in 12 years.
Cornerback Adam Jones intercepted Brady at the Cincinnati three-yard line with 16 seconds remaining to seal the win. The Bengals sacked Brady four times and limited him to 197 yards
Saints 26, Bears 18
Drew Brees threw two second-quarter touchdown passes to running back Pierre Thomas and the New Orleans Saints, despite missing several chances to break open the game, easily defeated the Chicago Bears to start the season with a 5-0 record.
The Bears had no defensive answer for tight end Jimmy Graham, who caught 10 passes for 135 yards, and New Orleans grabbed a 20-7 halftime lead.
Chicago made the final score look respectable, however, when Jay Cutler threw a two-yard touchdown pass to Brandon Marshall with 2:11 remaining in the fourth quarter and Matt Forte ran for a two-point conversion.
Chiefs 26, Titans 17
The Kansas City Chiefs kept their perfect record intact with a victory over the Tennessee Titans.
The Chiefs were down 17-13 late but took the lead for good on a one-yard touchdown run by Jamaal Charles with 6:27 left.
Charles had 108 yards rushing and 37 receiving.
Packers 22, Lions 9
The Green Bay Packers beat the Detroit Lions for the 23rd consecutive game, downing their NFC North rivals.
The Lions, who started the day atop the division, were without receiver Calvin Johnson (knee), who was a surprise scratch after being limited at Friday's practice.
The Packers couldn't take charge until the third quarter. Nursing a 9-3 lead, quarterback Aaron Rodgers hit James Jones for an 83-yard touchdown and Green Bay cruised to improve to 2-2.
Rams 34, Jaguars 20
St. Louis scored 17 unanswered second period points and established a 24-10 halftime lead before nursing it through the second half for a victory over winless Jacksonville.
After a slow start, Sam Bradford warmed up and finished 19 of 34 for 222 yards and three scores, while Jaguars QB Blaine Gabbert injured his hamstring in the third quarter.
Ravens 26, Dolphins 23
Justin Tucker kicked a 43-yard field goal with 1:42 left in the game to lead the Baltimore Ravens over the Miami Dolphins.
It was Tucker's fourth field goal of the game and held up after the Dolphins' game-tying try by rookie Caleb Sturgis from 57 yards missed wide left in the final seconds.
The Ravens (3-2) started their winning drive on their own 40 with 4:07 left. Ravens quarterback Joe Flacco, who passed for 269 yards, directed the winning drive to subdue the Dolphins (3-2).
Eagles 36, Giants 21
Nick Foles threw for two touchdowns and led four scoring drives after taking over for an injured Michael Vick late in the second quarter and Philadelphia dropped the Giants to 0-5.
Three fourth-quarter turnovers by quarterback Eli Manning led to 14 Eagles points and the Giants slipped to their worst start since in a non-strike season since 1979.
Vick left the game with a hamstring ailment.