Locker sprained his right hip and knee against the New York Jets on Sept. 29 and missed the last two games.
Ryan Fitzpatrick started the last two games for the Titans.
Locker completed 62.2 percent of his passes for 721 yards with six touchdowns and no interceptions in his first four games.
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The Denver Broncos have activated linebacker Von Miller in time for Sunday's game at Indianapolis.
Miller, 24, returned to practice this week after serving a six-game suspension for violating the NFL's substance-abuse policy.
Coach John Fox said he expected Miller to make an immediate impact.
"I think it's probably fair to say he's going to start," Fox said. "We're probably not going to announce the starting lineup but I wager he's going to start."
The 2011 NFL defensive rookie of the year has 30 sacks in his first two seasons, including a franchise-record 18 1/2 last season.
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New England Patriots tight end Rob Gronkowski travelled with the team for Sunday's game at the New York Jets, but cornerback Aqib Talib did not make the trip, according to the Boston Herald.
Gronkowski was finally cleared to play this week after off-season back and forearm surgeries. Gronkowski had complications in recovering from a broken forearm, which included four operations. He has practiced with the team since the beginning of the regular season. He is listed as questionable on the team's injury report.
Talib was listed as doubtful with a hip flexor injury.
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Former Houston Oilers and New Orleans Saints coach Bum Phillips died on Friday. He was 90.
His death was confirmed by son Wade Phillips, the Houston Texans' defensive coordinator, via Twitter.
"Bum is gone to Heaven -- loved and will be missed by all -- great Dad, Coach, and Christian," his son wrote.
Phillips was best known for turning the Houston Oilers into an AFC contender in the late 1970s. He coached the Oilers from 1975-80 and the Saints from 1981-85. He had a career NFL record of 86-80.
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Minnesota Vikings running back Adrian Peterson is listed on the team's injury report as probable for Monday night's game against the New York Giants.
Peterson practiced Saturday but was limited this week with hamstring tightness. Still, coach Leslie Frazier said he expects him to play.
Left tackle Matt Kalil is questionable with back tightness. He missed practice Friday and Saturday but Frazier also said he should play.
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New York Giants running back Brandon Jacobs and defensive end Jason Pierre-Paul missed practice Saturday and are questionable for Monday's game against the Vikings.
Jacobs has a hamstring injury and Pierre-Paul has an illness.
If Jacobs does not play, Peyton Hillis and Michael Cox are the only healthy tailbacks for the Giants. David Wilson (neck) and Andre Brown (leg) are out.
Pierre-Paul has 15 tackles and one sack this season.
Cornerback Jayron Hosley (hamstring) also is out, tight end Adrien Robinson (foot) and safety Cooper Taylor (shoulder) are questionable, and center David Baas (neck) and cornerback Terrell Thomas (knee) are probable.
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The Baltimore Ravens activated inside linebacker Jameel McClain from the physically unable to perform list and he is listed on the team's injury report as probable Sunday against the Pittsburgh Steelers.
McClain has been out since December when he bruised his spinal cord in a game against the Washington Redskins.
Doctors told McClain at the time that the injury would end his career but he was later given a more encouraging diagnosis.
The three-year starter returned to practice on Wednesday.