Ennis-Hill was due to make her season appearance in Estonia this weekend but for the third straight competition she has withdrawn, citing problems with overcoming an ankle injury.
She will now reset her sights on making the British Championships in Birmingham next month, where she usually competes across a range of events and will hope to defend her high jump and 100m hurdles title.
Ennis-Hill said: “I have been running and putting some force through the ankle, but (coach) Toni (Minichiello) and I feel that doing a heptathlon is not the best option to achieving a full recovery, and day by day it is feeling much more free and comfortable.
“This season’s focus has to still be the heptathlon in Moscow and there are many other options to compete before then.”
Minichiello insisted there would be no problem if Ennis-Hill didn't compete a heptathlon before travelling to Russia.
She won the world title in 2009 but settled for silver two years ago in Daegu behind Russia's Tatyana Chernova.
He said: “Jessica does not need to do a heptathlon before Moscow - but it would have been useful.
“However, given her ankle is making slow but steady progress and things are looking much better we don’t feel it is worth rushing it to compete this weekend in all seven disciplines.
“My job is to get her to Moscow in one piece, and in good shape, and that is my priority.”
Meanwhile, British Athletics have confirmed that promising sprinter Delano Williams is now eligible to compete for Great Britain this summer.
Last year's world junior 200m champion holds dual citizenship for both Turks & Caicos and Great Britain.
He was previously eligible to compete for the British team at the Olympics due to the Caribbean island's status as a British overseas territory, but narrowly missed out on selection.