First baseman Mark Teixeira will miss eight to 10 weeks with a strained right wrist, manager Joe Girardi announced on Wednesday.
Meanwhile, closer Mariano Rivera will make his first appearance on the mound since last May when he pitches in a spring training game this weekend.
Rivera last pitched in a game on April 30 in Yankee Stadium against Baltimore. Three days later, he suffered a season-ending knee injury during batting practice, and he had surgery in June.
"We're going to shoot for Saturday," Girardi told the YES Network. "We're not going to rush it. We have plenty of time."
Teixeira will rest his wrist completely for four weeks before beginning rehab work. His projected return would be sometime in May.
The injury, originally thought to be a strained forearm, occurred on Tuesday while Teixeira was hitting off a tee in Glendale, Arizona, before an exhibition game. He immediately was removed from the Team USA roster for the upcoming World Baseball Classic.
Kansas City Royals first baseman Eric Hosmer will take Teixeira's spot on the USA roster.
With Teixeira sidelined, the Yankees' options at first base include Juan Rivera, Dan Johnson and Kevin Youkilis.
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Longtime St. Louis Cardinals fan favorite Willie McGee is rejoining the team as a special assistant to general manager John Mozeliak.
"Willie has a wealth of experience in the game, and he is eager to pass on his observations and teachings," said Mozeliak in a statement. The St. Louis Post-Dispatch said McGee's primary duties would involve working with minor-leaguers.
McGee spent 13 of his 18 years with the Cardinals, winning two batting titles and three Gold Glove awards. He was the National League Most Valuable Player in 1985 with a league-leading .353 batting mark, helping the Cardinals to an NL championship.