San Antonio got a balanced attack, with all 12 of their players registering points, as they systematically broke down the visiting Raptors and ended Toronto's best stretch of the season.
Tim Duncan led the way with 15 points, Manu Ginobili added 14 off the bench and the Spurs (22-8) stretched their Southwest Division lead to two games over Memphis with the win.
None of Toronto's (9-20) starters reached double-figures in scoring.
The Raptors had managed to string together a succession of victories prior to Wednesday's game despite missing center Jonas Valanciunas, who broke his finger last week, and guard Kyle Lowry and forward Andrea Bargnani through injury.
(Reporting by Jahmal Corner in Los Angeles; Editing by Greg Stutchbury)