The Thunder grabbed their seventh consecutive victory, and their 16th win of the new season (16-4), while leaving the Lakers at 9-11.
After trailing by one point after the first quarter, the Thunder exploded in the second with 41 to open up a 14-point lead at the half, a gap the Lakers could not reel in.
The battle of the scoring big guns went to Thunder forward Kevin Durant with 36 points and nine rebounds, while Lakers guard Kobe Bryant finished with 35 points.
Oklahoma guard Russell Westbrook had a huge first half, scoring 27 of his 33 points to help the Thunder open up the big gap. (Reporting by Ben Everill in Los Angeles; Editing by Peter Rutherford)