The Frenchman blew away the rest of the field, shooting clear to come home in 23:51.5, 16 seconds clear of Russia’s Evgeny Ustyugov.
Another Russian, Andrei Makoveev, completed the podium, with Fourcade’s closest challenger in the overall standings, Norway’s Emil Hegle Svendsen, coming home in fourth.
Fourcade, who won the overall World Cup title last season, was clearly in top form having already led France to victory in the relay on Thursday.
And he was not to be denied in Germany, wrapping up his fourth World Cup success of the season so far.
The 24-year-old now has 504 points, 63 points clear of Svendsen, with Utyugov in third.