The clash had been scheduled for the Boardwalk Hall in Atlantic City on May 18, and was to be Alexander’s first defence of his IBF crown - but a foot injury to Brook means that it is now off.
The proposed bout between Brook and Alexander had already been cancelled twice due to each man succumbing to training injuries, but it seemed that the champion and the number one contender were finally ready to meet.
Brook's promoter Eddie Hearn issued a statement on Monday giving the latest bad news, however:
“Kell has recently developed pain in his right foot. Following specialist review and investigations over the last ten days he has been diagnosed with a stress fracture of his right fourth metatarsal and a further injury of his right navicular, both of which require on-going treatment including withdrawal from full training," Hearn said.
“As a result of these injuries and the time required to recover he has been advised that he will not be medically fit to fight on May 18.
“Obviously this is a huge blow and Kell is devastated but we have had to make the right decision for Kell Brook the fighter. We will speak with Golden Boy and hope to reschedule the bout in the near future.”
St Louis native Alexander (24-1, 13 KO’s) has already won world titles in two divisions despite being only 26. He is the former IBF and WBC world light welterweight title holder with wins over Lucas Matthysse, Juan Urango and Junior Witter.
In 2012, ‘The Great’ made his move to welterweight and defeated world champions Marcos Maidana and Randall Bailey, picking up the IBF title.