Supporting the main event will be Chris Eubank Jr and WBC International champion Kid Galahad.
The bout comes in place of the planned meeting with Kenny Anderson, which fell through at the last minute.
DeGale, ranked number three by the WBC, said: “Zuniga is a big test for me as he’s only lost to world class opponents in Kelly Pavlik, Lucian Bute and Tavaris Cloud.
“More recently he went 12 rounds with the unbeaten, highly world ranked South African, Thomas Oosthuizen, so it shows he is world class and a dangerous opponent.”
Promoter Mick Hennessy said: “In only 14 fights for James to be European champion and now fighting for the WBC Silver belt is shows the phenomenal talent he is.
“Styles make fights and these two are going to gel to make an explosive encounter.”
Colombian Zuniga said: "I want to fight James DeGale because it gives me the opportunity to win against an Olympic gold medallist.
“I have fought the best in the world but DeGale does not have my experience so I will win this fight.
“He has lost before and so he will lose again to me. I am a pressure fighter and I will fight him and pressure him in the ring until he gives up.”
DeGale replied: “He might not think I have his experience but he will have a different view after I beat him on the 8th.”
The undercard will feature Hull’s Samir Mouneimne Jr challenging the Scottish Area super featherweight champion David Savage over 10 rounds in a British flyweight title eliminator.
Hull-based fighters Ricky Dudding, Mike Oram, Nathon Smith and Joel Haigh will also be in action, as will Goole’s Zac Collins and Jordon Gill from Chatteris.