Belfast's Jackal was originally due to box Argentinian Fabian Oscar Orozco (20-3-2), until Orozco was stopped in the second round on June 28 in Santa Fe.
Although 26 of Briceno's 35 victories have come inside the distance, he hasn't won a fight outside Nicaragua in three attempts. He's contested the WBO super flyweight title on two occassions; in 2005, losing by decision to Fernando Montiel in Las Vegas, and in 2010 against Argentinian Omar Andres Narvaez.
His most recent title attempt came in 2011 against Leo Santa Cruz in Argentina, where he was stopped in the eleventh round contesting he WBC 'Youth' title at the age of 33.
This will be Frampton's first outing since recording his most impressive win yet against European champion Kiko Martinez, stopping him in the 9th round in Belfast. Martinez gets to fight for the full weight IBF super bantam title August 17 in Las Vegas against Colombian Jonathan Romero.
"I am in the best shape of my life right now. I am improving in training every day, sparring great, and I'm looking forward to showcasing my skills at Wembley on the 20th," said Frampton.
Headlining the show is a heavyweight clash between Dereck 'Del Boy' Chisora and unbeaten American Malik Scott. Billy Joe Saunders and Gary O'Sullivan clash for O'Sullivan's WBO International Middleweight title, and there's appearances from Scottish light heavy Callum Johnson, Bradley Saunders, Bradley Skeete, Billy Morgan, Tom Baker and Joey Taylor.
Ellesmere Port's Paul Butler will not challenge for the WBO Intercontinental super-flyweight title on the card after he injured his hand in his last fight against Najah Ali.