Fury stopped Joey Abell in his first bout in 10 months following the double-cancellation of his proposed domestic megafight with David Haye, despite being considerably over his best fighting weight.
The unbeaten fighter extended his professional streak to 22 by forcing the referee to halt the bout in the fourth round.
In the main event, Chisora did what Fury also did in late 2012 by scoring a tepid unanimous decision win over Kevin 'Kingpin' Johnson.
'Del Boy' dropped Johnson in the fifth with a trademark overhand right, but other than that had to settle for outworking his notoriously sluggish opponent over the course of the 12.
Promoters Frank Warren and Mick Hennessy plan to put the two victors together in a stadium rematch in the summer. Fury outpointed a out-of-sorts Chisora back in 2011, only for the Zimbabwe-born man to put on a solid run of victories while Fury's career stalled over the last year.
On the Copper Box undercard, Warren projects Frank Buglioni, Bradley Skeete and Georgie Keen all picked up wins, as did Fury's teenage cousin Hughie.
Steve Collins Jr, however, could not do the same. The son of the Irish super-middleweight star had his bout ruled a draw over four rounds.