A report in the Daily Mail claimed that the British former two-time world champion had pulled out of an IBF welterweight world title clash with Devon Alexander in December to facilitate a meeting with Mayweather early next summer.
"Team Khan would like to dispel recent reports that Amir Khan has pulled out of a potential match-up against Devon Alexander on December 7th, taking up a fight against Floyd Mayweather in May of next year instead," a statement said.
"Contrary to this story, Amir Khan is currently in training camp in San Francisco with the aim of fighting again in December against Alexander once an agreement can be reached."
Khan is set to meet Alexander before Christmas, with just the venue, either New York or Dubai, to be decided.
Initially, it was claimed that the clash with Mayweather would be the most lucrative bout ever to involve a British boxer, with Khan set to net no less than $6m (£3.7m) from the $200m mega-fight. That figure would reportedly climb to at least double that from pay-per-view television sales.
The Daily Mail said an official announcement would be made in the next few days.