Edinburgh head coach Michael Bradley admits their trip to Ulster is "daunting" but he has urged his players to view it as an opportunity to turn around their faltering season.
Edinburgh have lost six consecutive games - including two Heineken Cup whitewashes against Saracens and Munster - while their hosts have won all eight of their matches in all competitions.
Bradley said: "It's a great challenge for us. We've had a disappointing run of late and have spoken about how great a place it would be to end that run, so we're approaching the game in a very positive frame of mind. Ravenhill has become a bit of a fortress so it's a daunting task."
He added: "They will be well supported and are on an unbeaten run but, from our point of view, we're desperate to get a win, we've trained well this week and are very focused and driven to do a job in Ulster."
Bradley has made five changes as both sides lose a number of players to their national teams ahead of the November internationals.
Scotland squad members Grant Gilchrist, Stuart McInally and Lee Jones all start, while prop Allan Jacobsen continues his recovery from a hamstring injury on the bench.
Sean Cox captains Edinburgh while Robert McAlpine, John Houston, James King and stand-off Gregor Hunter all come in.
New lock Izak van der Westhuizen could make his debut off the bench after flying in from South Africa on Wednesday to complete his transfer from Free State Cheetahs.
Bradley added: "Izak is a quality player and a pretty robust character in terms of his ball carrying. He moves well as we saw in training, though it was a tough day for him after stepping off the plane, into a medical, and then out to training.
"He's enthusiastic and desperate to play, and will bring an added a physical dimension to our game."