England boss Roy Hodgson handed debuts to Birmingham goalkeeper Jack Butland and Manchester United midfielder Tom Cleverley for the friendly international with Italy in Berne.
By playing, Butland becomes England's youngest-ever stopper at 19 years and 158 days, beating the 124-year record of Billy Moon by 64 days.
Cleverley, who was 23 on Sunday, partners skipper Frank Lampard and Michael Carrick in the centre of the midfield.
Ashley Young is the only survivor from the England side which started the Euro 2012 quarter-final with Italy in Kiev in June, while Adam Johnson was also named in a wide role, with Andy Carroll selected as a lone striker.
Gary Cahill and Kyle Walker, who both missed Euro 2012 through injury, were picked in defence, with Everton duo Leighton Baines and Phil Jagielka completing the quartet at the back.