Igor Campedelli acted after younger sibling Nicola Campedelli oversaw three defeats in the relegated club’s opening three Serie B matches.
He had only taken the reins this summer, after Cesena were relegated from the top flight, making it a swift sacking even by Italian standards, where coaches are chopped and changed sometimes on a monthly basis.
"On Sunday night (after a 4-1 home defeat to Novara) I had to make a particularly tough decision for me, one which went beyond family ties and in the interest of Cesena and Cesena only," chairman Campedelli said.
"Nothing has changed between me and Nicola – we had lunch (on Monday) to make the situation less severe. We thought we had a long-term project but it was not successful and we must turn the page."
Campedelli’s decision to appoint his own brother as coach was itself a controversial one – the former Cesena midfielder is only 33 and had previously managed in Italy’s semi-professional leagues.
Now he has turned to a more experienced tactician in Pierpaolo Bisoli, a 45-year-old former player who has managed Cesena before and was in charge of Bologna at the start of last season.
"My first thoughts are for Nicola, and to wish him luck," Bisoli said. "I am very happy to be back, Cesena is like my home.
"I hoped to find a better atmosphere but when you change coach it means things aren’t going well. From now on I will try to improve the levels of enthusiasm.
"The team lacks confidence and I have to instil a winning mentality. I don’t live in the past but I came back because it is an important club."