The Magpies could secure European football for next season with a victory over Stoke on Saturday and, in the process, strengthen their claims on Champions League qualification.
But amid speculation that a series of Premier League rivals are ready to test their resolve to hang on to the likes of goalkeeper Tim Krul, midfielder Cheick Tiote and leading scorer Demba Ba, the club's fans will approach the latest transfer window with some trepidation.
Cisse, whose 10 goals in nine games since his January arrival from Freiburg have lit up Tyneside, admits he would be particularly disappointed to lose either Tiote or strike-partner Ba.
He told the Northern Echo: "Yes, I would be worried if they left because they have helped me a lot. It may effect me because of that but, at the end of the day, that's football and if a big opportunity came along for them to move, they can.
"But I would love for them to stay and play here longer because we are doing very well together. It's down to Newcastle, they will do the right thing. At the end of the day, I trust the club and they will do the right thing."