“Pirlo was coming off a muscular problem and did brilliantly to resist throughout the entire match with Spain,” explained Italian team doctor Professor Enrico Castellacci.
“However, as a precautionary measure and in agreement with the Coach, we have decided not to risk him for the next game.
“Barzagli is suffering from a recurring tendon problem that had already affected him recently.”
The defender was forced off at half-time in the semi-final against Spain.
Cesare Prandelli is expected to widely rotate the squad, as 120 minutes and a penalty shoot-out against Spain in severe heat on Thursday evening took its toll.
Italy’s game with Uruguay will kick off at 13.00 local time, so the atmospheric conditions are going to be tougher than ever for the players.