England Lions opener Carberry was in superb form, smashing 18 fours and five sixes, including the winning shot off Simon Kerrigan at the end of the 34th over. In total Carberry faced 115 balls and the toothless Lancashire attack had no answer to his ferocious assault, overwhelmed by the power and aggression of his shot-making.
In reply to Lancashire's barely adequate 244 for six, after being put in, champions Hampshire raced to 250 for one with six overs to spare in this floodlit encounter. Hampshire have now won four of their five matches while dejected Lancashire are still looking for their second victory.
Carberry shared in an opening stand of 77 in 11 overs with James Vince and then in another of 172 in 23 overs with captain Jimmy Adams without being parted.
Lancashire captain Simon Katich, a former Hampshire player, must have regretted losing the toss as openers Stephen Moore and Steven Croft were back in the pavilion with only 29 on the board, but they were redeemed by veteran South African Ashwell Prince, who made only his third limited overs century in 239 matches around the world.
Prince made 100 off 85 balls with a six and 11 fours before being caught at the wicket off Sean Ervine the ball after completing his hundred. Prince shared in a stand of 112 in 17 overs for the third wicket with Karl Brown, who made 44 before being in the deep by Chris Wood off Liam Dawson.
Gareth Cross and Wayne White ensured Prince's solid contribution was not wasted with a sixth wicket stand of 59 in eight overs before Cross was dismissed for 36 to the last ball of the innings.
Any hopes Lancashire harboured in being able to defend their total soon vanished in a hail of big shots from Carberry and Vince. Vince departed to a catch at square leg by Brown off Kyle Hogg but the experienced Adams made sure this was only a temporary setback for rampant Hampshire.
Adams, content to let Carberry take apart the Lancashire attack, finished with a valuable 66 not out but the evening belonged to the once-capped former England batsman.
Carberry was given a standing ovation as he made his way back to the dressing room by supporters who will not quickly forget his spectacular butchering of the Lancashire bowling.