England's Twenty20 international with India next summer, and a NatWest fixture against Australia a year later, will be re-awarded to another venue after Durham opted out of hosting the matches.
The ECB confirmed the move in a press release that also revealed that international cricket would be guaranteed at Chester-le-Street until 2016.
ECB chief executive David Collier said Friday's announcement was made to accommodate "Durham's long-term business plan".
The venue, which held its first international match during the 1999 World Cup, will stage an Ashes Test for the first time later this summer.
"Today's announcement is in line with Durham's long-term business plan and means that the club will host an optimal number of major matches over the four-year period whilst allowing the north-east region to continue to benefit from regular international cricket," Collier said.
England will play limited-overs matches against Sri Lanka (2014) and New Zealand (2015) at the ground before Sri Lanka return for a 2016 Test.