Gale, who batted almost nine hours for his 272 against Nottinghamshire at Scarborough last week, had been at the crease for another five hours of the Division One encounter, racking up 103 runs before he was leg-before to off spinner Ollie Rayner.
Gale had earlier lost Alex Lees - with whom he had shared a third-wicket partnership of 145 - to the first ball of the morning from James Harris before another batsman in fine form, Adil Rashid, made an impressive 72. Steven Patterson then dismissed Sam Robson to leave the visitors on top.
Derbyshire duo Shivnarine Chanderpaul and Wayne Madsen dominated on the opening day against Nottinghamshire at Trent Bridge.
After Chesney Hughes made 59 during the morning session, Chanderpaul and Madsen combined to put on an unbroken 145 before rain wiped out most of the final session with their side on 245 for two.
Champions Warwickshire bowled out Durham for 267 on the first day at Chester-le-Street.
Mark Stoneman was out for a duck to the second ball of the match from Keith Barker, setting the tone for the remainder of the day. Barker went on to finish with four for 41, including the scalp of Stoneman's opening partner Keaton Jennings (33).
Only Ben Stokes' 61 offered any real resistance from Durham, who were all out inside 87 overs.
In reply, Warwickshire were 31 for one at stumps, Ian Westwood then man out for five.
Sussex were frustrated in their bid to strengthen their position at the top of Division One after rain washed out the first day of their game against Surrey at Arundel Castle.