Australia travel to England for the eight-team tournament having suffered a humiliating 4-0 Test series loss on the subcontinent in March. But Hughes believes it is important to use that setback as a springboard to better performances ahead of the Ashes series, which begins in July.
"It was a tough tour, no doubt about it. But I think you can come out the other side of that a better player and that's what all the guys have spoken about," he said.
"That tour is over and done with now. To get knocked down like that, it can be tough but mentally it makes you stronger I feel and will only make the group stronger going forward into this one-day series and the Ashes."
Australia announced their 16-man squad for the Ashes last week and Mitchell Starc, a key part of the tourists' pace attack, has hailed the strength in depth among the bowling ranks.
"I think our fast bowling, we've got a good group of guys, even guys in domestic cricket who can come straight in if need be and play for Australia," he said.
"So I think fast bowling is in a good place at the moment. We've obviously got strong competition for spots."
John Inverarity, Australia's chairman of selectors, added: "We think it's a very good and very well-balanced squad, and we're looking to regain the Champions Trophy that we've won on the last two occasions."