James Anderson, Ian Bell, Stuart Broad and Graeme Swann, all key figures in England's 3-0 Test series win over Australia in the Ashes, join the skipper in sitting out the limited overs matches.
Pace bowler Chris Jordan and Jamie Overton and batsmen Gary Ballance and Boyd Rankin are in line for their England debuts, while Michael Carberry - who has one Test cap to his name - will make his England debut at one-day level.
England face Ireland at Malahide Cricket Club on Tuesday, September 3 before returning home to face Australia with the first match of a five-match series at Headingley on September 6.
“Following a very intense period of cricket this summer we have decided to rest a number of senior players which will allow them to recover from a heavy workload over the last three months and to prepare for the tour of Australia which begins in eight weeks," said national selector Geoff Miller.
“This creates an excellent opportunity for players who have impressed in county cricket and for England Lions recently to test themselves at international level as we continue to build a squad ahead of the ICC Cricket World Cup which is less than 18 months away.
“There are a number of very experienced one day players in the squad alongside players who are new to international cricket and we are expecting a very tough challenge both from a strong Ireland side and then from Australia in what will no doubt be a very competitive NatWest series.”
England ODI squad v Ireland on September 3
Eoin Morgan (Middlesex) (capt), Gary Ballance (Yorkshire), Ravi Bopara (Essex), Danny Briggs (Hampshire), Jos Buttler (Somerset), Michael Carberry (Hampshire), Steven Finn (Middlesex), Chris Jordan (Sussex), jamie Overton (Somerset), Boyd Rankin (Warwickshire), Ben Stokes (Durham), James Taylor (Nottinghamshire), James Tredwell (Kent), Luke Wright (Sussex)
England ODI squad v Australia for five-match series from September 6-16
Eoin Morgan (Middlesex) (capt), Ravi Bopara (Essex), Jos Buttler (Somerset), Michael Carberry (Hampshire), Steven Finn (Middlesex), Chris Jordan (Sussex), Jamie Overton (Somerset), Kevin Pietersen (Surrey), Boyd Rankin (Warwickshire), Joe Root (Yorkshire), Ben Stokes (Durham), James Tredwell (Kent), Jonathan Trott (Warwickshire), Luke Wright (Sussex)