Siddle, returning to the scene of his Test hat-trick against England three years ago, has Pietersen - and opposing captain Alastair Cook - specifically in his sights.
The tireless seamer will ready himself for the task on his daily intake of 20 bananas, as part of the "plant-based" diet the strict vegetarian and his health-conscious girlfriend Anna have devised for themselves.
There are no half-measures these days for the former Melbourne wood-chopper, who famously made mincemeat of England in the first innings of the 2010/11 Gabba Test before the tourists fought back to secure a draw which set them on their way to series victory.
Asked about the details of his food intake, the 28-year-old said: "It can vary from anywhere between 15 or 20 bananas a day.
"It's fruit-based, and a lot of vegetables.
"It keeps me healthy and strong."
He is confident it will sustain him through a tough Ashes series, and allow him to spoil England batsman Pietersen's landmark century of Test caps.
"That's the plan," said Siddle, speaking at a Cricket Australia 'fan-day' appearance by the entire home squad in front of shoppers at Brisbane's Queen Street Mall.
"It'd be nice to have wrecked it before then ... we'll see how we go."
Siddle, who has dimissed Pietersen seven times in 12 Test match meetings, respects him as a world-class opponent - but appears to sense he may yet end up hastening the 33-year-old's retirement on the back of a losing Ashes.
He added: "It's always a tough contest to play against him, a challenge.
"It's good fun ... I've bowled all right against him, the last couple of times.
"(We want to) keep building that pressure, and try to make it a not very memorable last series for him - if it is his end."
Pietersen is one of Siddle's two prize catches this winter.
"We've always targeted Cook.
"He's the man that opens up the batting; he's the captain and he's the one we want to put the pressure on."
However he fares, he will just keep eating his greens - and yellows.
An apple a day supposedly keeps the doctor away, but Siddle clearly believes a banana an hour has the opposite effect on wickets.
"I live on a plant-based diet now. That's my lifestyle.
"My partner has been vegetarian, vegan all her life.
"I've had a few niggles throughout my career, and did a lot of research about different ways of approaching my game.
"That's the route I've gone down, and it's working.
"I'm feeling fit, feeling strong, and hope I can get stuck in throughout this series."