The Briton will take part in the three-day stage race as he bids to get his preparations for the Tirreno-Adriatico back on track, following the cancellation of the Kuurne-Brussel-Kuurne last weekend.
Cavendish will be joined by OPQS team-mate and last year's overall winner of the race Julien Vermote.
"The race will be similar to last year's race, and last year we won with Vermote," said directeur sportif Tom Steels.
"The most important stage will be the one on Sunday with the climb of Monteberg and Kemmel. Last year this stage was really difficult because of terrible weather conditions.
“We will count on a very strong group of riders for this race, including Niki Terpstra - who is in good condition - and Gert Steegmans, who will start working on setting up the sprint and his leadout with Mark.
"Our objectives are to try and win a stage and repeat the good GC results of 2012. We have the potential to do that."
Omega Pharma-Quick Step squad: Dries Devenyns, Frantisek Rabon, Gert Steegmans, Iljo Keisse, Julien Vermote, Kristof Vandewalle, Mark Cavendish, Niki Terpstra.