The Germany international, 19, signed a new contract this week, putting to bed speculation he would leave in the summer.
And, despite returning to training after two months out injured, he will not feature as Juergen Klopp’s side look to extend their five-point lead over second-placed Bayern Munich.
"As things stand now everyone else is fit and ready for Stuttgart," Klopp, who will also be without injured Felipe Santana, said.
Goetze was key in last season's title run and had been outstanding until his injury in late January.
His comeback in time for what could become a title decider against second-placed Bayern Munich on April 11 is good news for the champions.