The carriage driving discipline has already been decided and with the showjuming and dressage finals not until April, all eyes will be on north Germany over the next few days.
Frenchman Andréani has won medals at most championships but a World Cup podium remains elusive, although he arrives in Brauschweig as the undisputed favourite to break that duck.
Andréani already has qualifying victories in Paris, Leipzig and Bordeaux under his belt, thanks to a run of consistently high marks, but the 28-year-old has proved in the past his fragility under pressure.
Czech Lukas Klouda is one rival set to capitalise should Andréani falter.
In the women's field, the competition appears more open even though Swiss Simone Jaiser is regularly mentioned among favourites.
Jaiser will be pushed by the likes of compatriot Pascale Wagner, German duo Regina Burgmayr and Kristina Boe, Italy's Anna Cavallaro and the Dutchwoman Carola Sneekes.
The first leg for both the men and women - compulsory movements - is scheduled for Saturday evening before the second leg - freestyle - will take place on Sunday morning.