Defoe broke the deadlock when he lashed home from inside the area before Nacer Chadli stroked home the second five minutes later after turning in Kyle Walker’s cut-back.
Tottenham kept it tight after the restart with chances at a premium as they comfortably saw out the win.
The Russians, best known for the summer exodus of former stars including Willian, Samuel Eto’o and Lassana Diarra, rarely threatened with Pavel Solomatin coming the closest when his drive from a tight angle forced Hugo Lloris to beat the ball away.
The win marked another clean sheet for the Tottenham defence as the North Londoners continued their perfect start in Group K.
34’ – GOAL: Anzhi 0-1 Spurs: Holtby receives the ball, delays his pass before slipping in Defoe who lashes into the roof of the net. Cracking finish.
39’ – GOAL: Anzhi 0-2 Spurs: Walker finds himself in a ridiculous amount of space down the right. He has so much time to pick out Chadli who strokes the ball home. 2-0. Too easy for Spurs.
85’ – CHANCE: Lovely one-touch passing appears to get Tottenham out of trouble but they concede possession which allows Anzhi to break forward. It comes to Solomatin on the right who sends a bouncing shot towards Lloris who does well to palm clear.
Jermain Defoe’s goal moved him to within one of Martin Chivers' club record in Europe of 22.
TALKING POINT: Can Spurs challenge on two fronts? AVB’s troops have enjoyed an impressive start to the season but given Tottenham are prone to a collapse would it not be wiser to focus solely on the Premier League? At present they can afford to rotate their squad fully, but that will inevitably change when injuries creep in, the fixtures become congested and the opposition in Europe get more tricky. All good so far for Spurs though who easily saw off the threat of Anzhi.
MAN OF THE MATCH
Moussa Dembele (Tottenham): Put in a proper shift at the heart of Spurs’ midfield and was often the link between defence and attack.
Anzhi: Pomazan 5, Angwba 6, Adeleye 5, Ewerton 5, Tagiberkov 5, Ahmedov 7, Jucilei 6, Serderov 5, Razak 5, Solomatin 7, Abdulavov 5… Subs: Yeschenko 6, Gadzhibekov 6, Traore 7.
Tottenham: Lloris 6, Walker 6, Chiriches 6, Kaboul 7, Fryers 6, Dembele 7, Sandro 7, Lamela 5, Holtby 7, Chadli 7; Defoe 7… Subs: Dawson 6, Eriksen 6, Sigurdsson 6.
THE MATCH IN A TWEET