Non-league Luton Town will fancy their chances against Championship side Millwall while Oldham's reward for their win over Liverpool is another home tie against Merseyside opposition with Everton coming to Boundary Park.
The ties will be played over the weekend of February 16/17.
FA Cup fifth round draw
Huddersfield Town/Leicester City v Wigan Athletic
MK Dons v Barnsley
Oldham Athletic v Everton
Luton Town v Millwall
Arsenal v Blackburn Rovers
Manchester City v Leeds United
Manchester United v Reading
Middlesbrough v Brentford/Chelsea