Demba Ba made an instant impact with two goals on his Chelsea debut as the holders romped to an emphatic 5-1 victory at Southampton in the FA Cup third round.
Newcastle United, the club Ba left on Friday, continued their dismal run of form with a 2-0 defeat at Championship side Brighton and Hove Albion - a rare upset on one of the most eagerly-awaited days in the English season.
Goals from Andrea Orlandi and Will Hoskins earned Brighton a repeat of their fourth round victory over Premier League Newcastle last season, condemning Alan Pardew's side to an 11th defeat in 14 matches.
Major shocks were non-existent although Cardiff City, currently romping away at the top of the Championship, were beaten 2-1 at non-league Macclesfield Town - who reached the fourth round for the first time.
Non-league Luton Town also beat second tier Wolverhampton Wanderers 1-0.
Several clubs struggling in the Premier League flirted with defeats against lower league opposition but survived.
Fulham drew 1-1 at home to Blackpool, League One Bournemouth earned a replay with Wigan Athletic after holding them to a 1-1 draw while Sunderland drew 2-2 at Bolton Wanderers who were relegated from the top flight last season.
Reading had to come from a goal down to beat League One Crawley Town 3-1 away.
South coast seventh-tier minnows Hastings United, the lowliest survivors of the 758 clubs which began the 132nd edition of the knockout competition in August, had their fairytale cut short in a 4-1 defeat at Middlesbrough.
Premier League champions Manchester City, winners of the competition in 2011, eased into the fourth round with a 3-0 defeat of Gianfranco Zola's Championship side Watford.
Tottenham Hotspur's fine run of form continued with Clint Dempsey scoring twice in a 3-0 home victory over third tier Coventry City, the side they lost to in the 1987 FA Cup final.
FULL FA CUP MATCH REPORTS
West Ham United 2-2 Manchester United - Upton Park, London
Brighton and Hove Albion 2-0 Newcastle United - Amex Stadium, Brighton
Barnsley 1-0 Burnley - Oakwell, Barnsley
Crystal Palace 0-0 Stoke City - Selhurst Park, London
Manchester City 3-0 Watford - Etihad Stadium, Manchester
Fulham 1-1 Blackpool - Craven Cottage, London
Charlton Athletic 0-1 Huddersfield Town - The Valley, London
Tottenham Hotspur 3-0 Coventry City - White Hart Lane, London
Wigan Athletic 1-1 AFC Bournemouth - DW Stadium, Wigan
Aston Villa 2-1 Ipswich Town - Villa Park, Birmingham
Macclesfield Town 2-1 Cardiff City - Moss Rose, Macclesfield
Leicester City 2-0 Burton Albion - King Power Stadium, Leicester
Crawley Town 1-3 Reading - Broadfield Stadium, Crawley
Aldershot Town 3-1 Rotherham United - Recreation Ground, Aldershot
Hull City 1-1 Leyton Orient - KC Stadium, Hull
Queens Park Rangers 1-1 West Bromwich Albion - Loftus Road, London
Middlesbrough 4-1 Hastings United - Riverside Stadium, Middlesbrough
Blackburn Rovers 2-0 Bristol City - Ewood Park, Blackburn
Oxford United 0-3 Sheffield United - Kassam Stadium, Oxford
Leeds United 1-1 Birmingham City - Elland Road, Leeds
Nottingham Forest 2-3 Oldham Athletic - City Ground, Nottingham
Southampton 1-5 Chelsea - St. Mary's Stadium, Southampton
Southend United 2-2 Brentford - Roots Hall, Southend-on-Sea
Sheffield Wednesday 0-0 Milton Keynes Dons FC - Hillsborough, Sheffield
Millwall 1-0 Preston North End - The Den, London
Derby County 5-0 Tranmere Rovers - Pride Park, Derby
Peterborough United 0-3 Norwich City - London Road, Peterborough
Bolton Wanderers 2-2 Sunderland - Reebok Stadium, Bolton
Luton Town 1-0 Wolverhampton Wanderers - Kenilworth Road, Luton